Sub-Acute Toxicological Evaluation of Roots of Stereospermum suaveolens

The present study was aimed to evaluate the subacute toxicity of ethanol extract of roots of Stereospermum suaveolens in Wistar rats. Ethanol extract of roots of Stereospermum suaveolens was prepared by hot extraction method. Acute toxicity studies had been carried out according to OECD 423 guidelines. Sub-acute toxicity studies were evaluated by orally administering the extract at dosage levels of 200 and 400 mg/kg b.w. for 28 days. At the end of the study blood was collected for haematological and biochemical specifications and animals were sacrificed and organ weights were monitored and subjected for histological studies. The results of the acute toxicity study shows that extract was safe at 2000mg/kg b.w. Sub-acute toxicity study did not show a significant change in any of the hematological and biochemical parameters. Further histological studies also substantiated the biochemical parameters. The findings of the present study conclude that the ethanol extract of roots of Stereospermum suaveolens was practically non toxic in rats after repeated oral administration. Further the study supports the use of roots of Stereospermum suaveolens in traditional systems of medicine.